Major Histocompatibility Complex Markers in Patients with Nomifensine-Induced Immune Hemolytic Anemia |
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| Authors: | Gertrud Mueller-Eckhardt G. Giers A. Salama Dolores J. Schendel G. Fass and C. Mueller-Eckhardt |
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| Affiliation: | Institute of Clinical Immunology and Blood Transfusion, University of Giessen, FRG. |
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| Abstract: | To evaluate a possible role of major-histocompatibility-complex (MHC)-related immune-response genes for the selective production of drug-induced antibodies, HLA class I (ABC), class II (DR, DQ), class III (BF, C2, C4A, C4B) as well as glyoxalase-1 allotypes were investigated in 26 patients with nomifensine-induced immune hemolytic anemia. No statistically significant deviations of MHC antigen frequencies were noted. The possible implications of these findings are discussed. |
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