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Dose‐dependent suppression of human photoparoxysmal response with the competitive AMPA/kainate receptor antagonist BGG492: Clear PK/PD relationship
Authors:Dorotheé Kasteleijn‐Nolst Trenité  Christian Brandt  Thomas Mayer  Felix Rosenow  Bernd Schmidt  Bernhard J. Steinhoff  Anne Gardin  Georges Imbert  Donald Johns  Alexandros Sagkriotis  Klaus Kucher
Affiliation:1. Child Neurology Division, Department of Pediatrics, Università “Sapienza” Roma, Rome, Italy;2. Department of General Epileptology, Bethel Epilepsy Centre, Bielefeld, Germany;3. Saxonian Epilepsy Center Radeberg, Radeberg, Germany;4. Department of Neurology, Epilepsy Center Hessen – Marburg, Philipps‐University, Marburg, Germany;5. Epilepsy Center Franfurt Rhein‐Main, Department of Neurology, Johann Wolfgang Goethe University, Germany;6. Neurology & Psychiatry Clinic, Wittnau, Germany;7. Epilepsiezentrum Kork, Kehl‐Kork, Germany;8. Novartis Institutes for Biomedical Research, Basel, Switzerland;9. Biogen Idec Inc., Cambridge, MA, U.S.A;10. Novartis Development, Basel, Switzerland
Abstract:
Keywords:α  ‐Amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid  Antiepileptic drugs  BGG492  Kainate  Photoparoxysmal  Selurampanel
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