CT灌注成像用于评估TACE联合阿帕替尼治疗中晚期原发性肝癌疗效的临床研究

目的 观察CT灌注成像(CTPI)用于评估经导管动脉化疗栓塞术(TACE)联合阿帕替尼治疗中晚期原发性肝癌疗效的应用价值.方法 纳入2017年3月至2019年3月期间我院收治的中晚期原发性肝癌(HCC)患者56例,均于我院首次行TACE联合阿帕替尼治疗,并在术前1～3d和术后1～2个月接受CTPI检查.观察治疗前后肿瘤...

Clinical Study on CT Perfusion Imaging Evaluating Curative Effect of TACE Combined with Apatinib on Middle and Advanced Hepatocellular Carcinoma

Objective To observe the application value of CT perfusion imaging(CTPI)in evaluating the curative effect of transcatheter arterial chemoembolization(TACE)combined with apatinib on middle and advanced hepatocellular carcinoma(HCC).Methods A total of 56 patients with middle and advanced HCC admitted to the hospital from March 2017 to March 2019 were enrolled.All were treated with TACE and apatinib for the first time in the hospital.Within 1-3 d before surgery and 1-2 months after surgery,all underwent CTPI exa mination.The changes of blood perfusion parameters[liver blood flow(BF),liver blood volume(BV),mean transit time(MTT),hepatic perfusion index(HPI),hepatic arterial perfusion(HAP),portal venous perfusion(PVP)]in tumor tissues before and after treatment were observed.Results After treatment,BF,BV,HPI,and HAP,in tumor tissues were significantly decreased(P<0.05).Before and after treatment,there were no significant changes in MTT and PVP in tumor tissues(P>0.05).After treatment,there were 38 patients with local residual tumors.BF,BV,HPI,and HAP in residual tissues were significantly higher than those in normal liver tissues(P<0.05),while MTT,and PVP were significantly lower than those in normal liver tissues(P<0.05).Conclusion CTPI can intuitively and comprehensively reflect the hemodynamic changes before and after TACE combined with apatinib treatment in patients with middle and advanced HCC,which provides the basis for further clinical treatment.