基于呼出气一氧化氮评估非急性咳嗽儿童的年龄与其机体激素应答的关系

目的探讨非急性咳嗽儿童的年龄与其机体激素应答的关系。方法连续性收集2014年5月-2016年4月就诊的非急性咳嗽儿童3824例,分析各年龄段的呼出气一氧化氮(eNO)水平及存在激素应答的比例;根据就诊儿童不同的eNO水平,比较年龄的差异;以存在激素应答为因变量进行多因素回归分析,评估不同年龄段儿童存在激素应答的风险。结果总体患儿eNO水平在14(10~25)ppb,e NO>35 ppb的儿童占14.2%;在不同的eNO水平,患儿年龄差异有统计学意义(P<0.01);相对于年龄≤3岁或≥10岁的患儿,4岁~9岁患儿存在激素应答的风险显著降低(P<0.05)。结论对于非急性咳嗽的患儿,年龄与eNO水平密切相关。

The relationship between age and glucocorticoid response in children with non-acute cough:A clinical study based on exhaled nitric oxide assessment

Objective To explore the relationship between age and glucocorticoid response in children with non-acute cough.Methods A total of 3824 children with non-acute cough were collected from May 2014 to April 2016 continuously.The levels of exhaled nitric oxide(eNO)and the proportion of glucocorticoid response in children of different ages were analyzed.The differences of age were compared according to different eNO levels in children.Multivariate regression analysis was conducted to assess the risk of glucocorticoid response in children of different ages.Results The total level of eNO was 14(10-25)ppb,and the proportion of children with eNO>35 ppb was 14.2%.There was statistical significance on the differences in age among children with different levels of eNO(P<0.01).Compared with children under 3 years old or over 10 years old,the risk of glucocorticoid response in children aged 4 to 9 years old was significantly lower(P<0.05).Conclusion Age is closely related to eNO level in children with non-acute cough.