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T淋巴细胞亚群在桥本氏甲状腺炎外周血中的变化及意义
引用本文:金妙妙,洪中武,王明政. T淋巴细胞亚群在桥本氏甲状腺炎外周血中的变化及意义[J]. 中国卫生检验杂志, 2020, 0(11): 1363-1364
作者姓名:金妙妙  洪中武  王明政
作者单位:金华市中心医院乳腺甲状腺外科
摘    要:目的检测桥本氏甲状腺炎(HT)患者外周血T淋巴细胞亚群的变化,初步探讨HT发病的免疫学机制。方法连续收集本院外科自2015年6月-2018年12月收治的HT初诊患者72例(HT组)另收集同期健康体检者25例作正常对照组(HC组),应用流式细胞仪检测二组外周血Th1/Th2细胞百分比。结果与HC组相比,HT组血清的TPOAb和Tg Ab水平明显增高(P <0. 05)。与HC组相比,HT组外周血Th1细胞百分率均明显增高(P <0. 05),而Th2细胞的百分率明显降低(P <0. 05),Th1/Th2平衡向Th1方向偏移(P <0. 05)。HT患者外周血Th1细胞百分比与血清TPOAb水平呈正相关(r值分别为0. 748、0. 672,P <0. 05)。结论 Th1/Th2细胞比例失衡及变化可能与HT发病机制有关。

关 键 词:桥本氏甲状腺炎  TH1细胞  TH2细胞  平衡失调

Changes and significance of T lymphocyte subsets in peripheral blood of Hashimoto's thyroiditis
JIN Miao-miao,HONG Zhong-wu,WANG Ming-zheng. Changes and significance of T lymphocyte subsets in peripheral blood of Hashimoto's thyroiditis[J]. Chinses Journal of Health Laboratory Technology, 2020, 0(11): 1363-1364
Authors:JIN Miao-miao  HONG Zhong-wu  WANG Ming-zheng
Affiliation:(Department of Breast Thyroid Surgery,Jinhua Municipal Central Hospital,Jinhua,Zhejiang 321000,China)
Abstract:Objective To detect the changes of T lymphocyte subsets in peripheral blood of patients with Hashimoto’s thyroiditis( HT),and to explore the immunological mechanism of HT. Methods Seventy-two patients( HT group) with HT who were admitted to our hospital from June 2015 to December 2018 were enrolled in this study,and twenty five cases for health examination were selected as the control group( HC group) at the same period. The percentages of Th1/Th2 cells in peripheral blood of the two groups were detected by flow cytometry. Results Compared with the HC group,the levels of TPOAb and Tg Ab in the serum of the HT group significantly increased( P < 0. 05). Compared with the HC group,the percentage of Th1 cells in the peripheral blood of the HT group significantly increased( P < 0. 05),while the percentage of Th2 cells significantly decreased( P < 0. 05),and the Th1/Th2 balance shifted to the Th1 direction( P < 0. 05). The percentage of Th1 cells in peripheral blood of patients with HT was positively correlated with serum TPOAb( r = 0. 748,r = 0. 672,P < 0. 05). Conclusion The imbalance and variation of Th1/Th2 cell ratio may be related to the pathogenesis of HT.
Keywords:Hashimoto's thyroiditis  Thl cells  Th2 cells  Balance disorders
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