肝豆状核变性颅脑MRI体素内不相干运动成像

目的探讨体素内不相干运动成像在肝豆状核变性颅脑MRI中的应用价值。方法收集21例临床确诊肝豆状核变性患者及21例健康对照者,均进行颅脑MRI常规扫描及体素内不相干运动成像(IVIM)序列扫描,经过工作站处理获得参数图,分别测量两侧豆状核及丘脑的ADC值、D*值、D值、f值(标准ADC值、快扩散ADC值、慢扩散ADC值、灌注分数)。比较肝豆状核变性患者与健康对照者各参数的差异。结果肝豆状核变性组与健康对照组相比,肝豆状核变性组豆状核的D*减低、f值增高,且有统计学差异(P<0.001);丘脑的ADC值增加、D*值减低、D值增高,并有统计学差异(其中ADC值和D值P<0.05,D*值P<0.001)。结论 IVIM基于双指数模型,使用多b值计算,可同时获得肝豆状核变性患者豆状核及丘脑的弥散及灌注信息,有助于进一步阐明其颅脑病变的发生机制。

Intravoxel Incoherent Motion Imaging in Craniocerebral MRI of Hepatolenticular Degeneration

Objective To explore the application value of intravoxel incoherent motion imaging in craniocerebral MRI of hepatolenticular degeneration.Methods 21 cases with clinical diagnosis of hepatolenticular degeneration and 21 cases of healthy control group were scanned by craniocerebral magnetic resonance imaging with routine sequences and IVIM sequences,obtail parameter maps through workstation,and then measure the ADC value,D*value,D value,f value(standard ADC value,fast diffusion ADC value,slow diffusion ADC value,the perfusion fraction f) of the bilateral lenticular nucleus and thalamus.The differences of the parameters between patients with hepatolenticular degeneration and healthy control group were compared.Results Compared with the healthy control group,D*and f values of the lenticular nucleus decreased and increased in the lenticular nucleus degeneration group,with statistical difference(P<0.001).The ADC value and D value of thalamus increased,the D*value decreased,with statistical difference(ADC value and D value P<0.05,D*value P<0.001).Conclusion IVIM is based on the dual-index model,and the calculation of multiple b values can concurrently obtain the diffusion and perfusion information of the lenticular nucleus and thalamus of patients with hepatolenticular degeneration,which is helpful to illuminating the occurre n ce mechanism of cra niocerebral lesions in hepatolenticular degeneration.