DHA对APOE4相关阿尔茨海默病影响的研究进展

阿尔茨海默病(AD)是导致老年人痴呆的主要原因。除年龄外,载脂蛋白E (APOE) 4等位基因是散发型AD最强的危险因素。饮食和补充摄入n-3脂肪酸DHA能降低AD的发病风险和改善AD症状。但是相关研究也产生了混乱的和不一致的结果。进一步研究发现,对APOE 4相关AD病人补充DHA的效果可能与补充量和时间、补充对象的疾病严重程度和补充的DHA的形式有关。APOE4携带者在AD临床症状较轻时大高剂量长时间补充DHA是降低AD发病率的有效途径;最好是通过膳食补充磷脂形式的DHA而不是DHA膳食补充。

Research progress on the effect of DHA on apoE4 related Alzheimer’s disease

Alzheimer’s disease(AD) is a major cause of dementia in the elderly. In addition to age,the apolipoprotein E(APOE)4 allele is the strongest risk factor for sporadic AD. Dietary and supplemental intake of the omega-3 fatty acid docosahexaenoic acid(DHA) reduces the risk of Alzheimer’s diseases(AD) and improve symptoms.But studies have also produced mixed and inconsistent results. Further studies have found that the effects of DHA supplementation in APOE4 related AD patients may be related to the amount and time of supplementation, the disease severity, and the form of DHA supplementation. When the clinical symptoms of AD are mild in APOE4 carriers, highdose and long-term DHA supplementation is an effective way to reduce the incidence of AD. It is best to supplement DHA in the form of phospholipids instead of DHA dietary supplements.