妊娠合并乙型肝炎感染与凝血、抗凝、纤溶实验室指标的相关性研究

目的检测凝血、抗凝、纤溶实验室指标,探讨在慢性乙型肝炎合并妊娠患者临床诊疗中的意义。方法选取2015年12月-2017年11月就诊的慢性乙型肝炎妊娠患者58例,未孕肝炎患者62例,正常晚孕组62例,对照组56例。检测PT、APTT、D-D、AT-Ⅲ、FDP,并对检测结果进行统计分析。结果妊娠肝炎组与对照组、正常晚孕组比较,PT、APTT、FDP、D-D、AT-Ⅲ各指标差异均有统计学意义(P<0.05),PT、APTT明显延长,FDP、D-D明显升高,AT-Ⅲ百分比明显降低。妊娠肝炎组与未孕肝炎组比较,FDP、D-D差异均有统计学意义(P<0.05)。HBeAg阳性妊娠组与HBe Ag阴性妊娠组比较,PT明显延长,FDP、D-D明显升高,差异有统计学意义(P<0.05)。结论多指标动态观察和综合判断对妊娠合并乙型肝炎感染病情判断、临床治疗、预后评估,降低死亡率有重要意义。

Study on correlation between hepatitis B infection and coagulation,anticoagulation and fibrinolysis laboratory

Objective Through the detection of blood coagulation,anticoagulation,fibrinolysis laboratory index,to discuss the clinical diagnosis and treatment of patients with chronic hepatitis B with pregnancy.Methods A total of 58 cases of chronic hepatitis B pregnancy patients who visited the hospital from December 2015 to November 2017,62 cases of non-pregnant hepatitis patients,62 cases of normal late pregnancy patients and 56 controls were selected to detect PT,APTT,D-D,AT-Ⅲ,FDP,and the testing results were analyzed.Results Compared with the control group and normal late pregnancy group,the differences of PT,APTT,FDP,D-D,and antithrombin-Ⅲindexes were statistically significant(P<0.05).PT and APTT were significantly prolonged,FDP and D-D were significantly increased,and the percentage of antithrombin-Ⅲwas significantly reduced.Comparison between the gestational hepatitis group and the non-pregnant hepatitis group showed statistical significance on the differences in FDP and D-D(P<0.05).Compared with HBeAg positive pregnancy group and HBe Ag negative pregnancy group,PT was significantly prolonged,FDP and D-D were significantly increased,and the differences were statistically significant(P<0.05).Conclusion Multi-index dynamic observation and comprehensive judgment are of great significance for the judgment of the condition of pregnancy combined with hepatitis B infection,clinical treatment,prognosis assessment,and reduction of mortality.