Diet and histologic types of benign breast disease defined by subsequent risk of breast cancer |
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Authors: | T G Hislop P R Band M Deschamps V Ng A J Coldman A J Worth T Labo |
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Affiliation: | Division of Epidemiology, Biometry and Occupational Oncology, Cancer Control Agency of British Columbia, Vancouver, Canada. |
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Abstract: | The authors investigated the relation between diet and histologic types of benign breast disease defined by subsequent risk of breast cancer in a case-control study of volunteers who entered the Vancouver Center of the Canadian National Breast Screening Study between 1983 and 1985. Proliferative benign breast disease (n = 124) was inversely associated with vitamin A supplementation (vitamin A user vs. nonuser, odds ratio (OR) = 0.5) and frequent green vegetable consumption (frequent vs. rare consumption, OR = 0.3), whereas severe atypias and borderline carcinoma in situ (n = 32) were directly associated with frequent meat fats consumption (frequent vs. rare consumption, OR = 3.2) with no association with vitamin A or vegetable consumption. No dietary relations were found for histologic types of benign breast disease at no increased risk for subsequent breast cancer (n = 274). The implications of these findings in relation to the etiology of breast cancer are discussed. |
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