血清结缔组织生长因子在肝纤维化评估中的临床价值

目的探讨血清结缔组织生长因子(CTGF)和肝纤维化的关系,评估结缔组织生长因子在肝纤维化诊断中的临床价值。方法应用酶联免疫吸附法(ELISA)测定血清CTGF水平,探讨血清CTGF浓度和肝纤维化程度的关系;通过CTGF和一些已经证实的肝纤维化标记物的ROC曲线分析,评估CTGF诊断肝纤维化的价值。结果血清CTGF水平和肝纤维化分期明显相关,r为0.689(P<0.001),CTGF用于鉴别轻微纤维化和明显纤维化的ROC曲线下面积为0.841,95%可信区间0.762~0.920。结论血清CTGF和肝纤维化分期明显相关,提示血清CTGF水平可能是预测肝纤维化分期比较好的标记物,血清CTGF在肝纤维化的评估中是一个非常有价值的指标。

The clinicam value of serum connective growth tissue factor(CTGF) in the assessment of liver fibrosis

Purpose To explore the relationship between connective growth tissue factor(CTGF) in serum and the severity of liver fibrosis,and to determine the clinical value of CTGF in the assessment of liver fibrosis.Methods Serums CTGF were tested utilizing enzyme linked immunosorbent assay(ELISA).The correlation between serum CTGF concentration and fibrosis stage was assessed.Results The diagnostic performance of CTGF was assessed by comparing the area under receiver characteristic curves(AUC) with a panel of fibrosis markers.Correlation coefficient was 0.689(P＜0.001) between the levels of serum CTGF and fibrosis stages and AUC of CTGF was 0.841(95% confidence interval,0.762-0.920) in distinguishing mild fibrosis from significant fibrosis.Conclusion The present data revealed that serum CTGF was significantly correlated with the stage of liver fibrosis,suggesting that serum CTGF was an indicator for the stage of liver fibrosis,and serum CTGF could be used as a valuable marker assessing liver fibrosis.