LAT在T细胞成熟分化中的作用

T细胞活化衔接因子(Linker for activation of T cells,IJAT)是一种Ⅲ型的跨膜蛋白,它不具有酶的活性,却能通过连接信号转导途径中的其他衔接蛋白或主要的酶而发挥重要作用.LAT参与多种细胞的信号转导,尤其在T细胞的成熟活化过程中起着重要的跨膜信号传递作用,当T细胞借助TCR识别由MHC分子递交的抗原肽后,LAT胞内段的酪氨酸发生磷酸化,继而募集到在T细胞激活中起重要作用的多种信号分子,对TCR信号转导和T细胞内环境稳定进行调节,在这一过程中,132、171、191和226四个位点的酪氨酸磷酸化起了关键性的作用.

The influence of linker for activation of T cells(LAT)on the development of T cells

Linker for activation of T cells(LAT)is a type Ⅲ transmembrane protein,which is not enzymatic active.LAT plays an important role in the intracellular signal transduction by linking other adaptor proteins or critical enzymes.LAT participates in the signal transduction of various kinds of cells,especially in the signal transduction for development of T cells.After recognizing the antigen peptides by TCR,the intracellular segment of LAT becomes tyrosine-phosphorylated and recruits multiple signaling molecules important for T cell activation,and regulates T cell development and homeostasis.The distal four tyrosine residues of LAT(Y132,Y171,Y191,and Y226)are important for its activity.