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| FTO基因与肥胖关系的研究进展 | |
| 引用本文： | 肖志华,郭武华,张吉翔. FTO基因与肥胖关系的研究进展[J]. 中国病理生理杂志, 2010, 26(5): 1025-1028. DOI: 1000-4718 |
| 作者姓名： | 肖志华 郭武华 张吉翔 |
| 作者单位： | 南昌大学1第二附属医院消化内科,2第二附属医院肿瘤科,3江西省分子医学重点实验室,江西 南昌 330006 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | <正>肥胖已成为严重危害人类健康的社会问题。现有大约十亿的成年人是超重,体重指数(body mass index,BMI)超过25,并且有3亿成年人是肥胖,BMI超过30。肥胖会导致严重的健康问题,降低生活期盼,对生活质量造成重要影响。肥胖和超体重会导致高血压、2型糖尿病、冠状动脉心脏病等严重疾 |
| 关 键 词： | 基因 FTO 单核甘酸多态性 肥胖 |
| 收稿时间： | 2008-11-11 |
| 修稿时间： | 2009-05-04 |
Research progress in FTO gene and obesity |
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| XIAO Zhi-hua,GUO Wu-hua,ZHANG Ji-xiang. Research progress in FTO gene and obesity[J]. Chinese Journal of Pathophysiology, 2010, 26(5): 1025-1028. DOI: 1000-4718 | |
| Authors: | XIAO Zhi-hua GUO Wu-hua ZHANG Ji-xiang |
| Affiliation: | 1Department of Gastroenterology, 2Department of Oncology, The Second Affiliated Hospital, 3The Key Laboratory of Molecular Medicine of Jiangxi Province, Nanchang University, Nanchang 330006, China. E-mail: Jixiangz@tom.com |
| Abstract: | Obesity is a rapidly growing international health problem. The association of fat mass and obesity associated(FTO) gene and obesity is becoming the hot topic in the gene research. FTO is a member of the non-heme dioxygenase ［Fe(Ⅱ) and 2-oxoglutarate-dependent dioxygenases］ superfamily. FTO levels in the brain, especially in the hypothalamus, participate in the central control of food intake. The mutation of FTO gene accentuates body mass index, hip circumference and total weight, leading to obesity. |
| Keywords: | Gene FTO Single-nucleotide polymorphism Obesity |
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