ELISA and indirect immunofluorescence in the diagnosis of LCM virus infections.

Thirty-seven matched samples of patient sera with the clinical diagnosis of a lymphocytic choriomeningitis (LCM) infection, as well as 56 matched samples of patient sera with the clinical diagnosis of a CNS infection of vague etiology were examined. Two serological techniques, indirect immunofluorescence (IF) and ELISA were used. They revealed 16.2% of positive sera confirming the clinical diagnosis of the disease; in the cases of clinical diagnosis of CNS infection of vague etiology 8.9% of positive sera were found, which points to an LCM virus-caused infection.