| 汉族和蒙古族维生素D受体基因多态性分布的研究 |
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| 引用本文： | 张红红,牟小芬,孟秀梅,高宇红,刘建伟,吴青,胡亚卓,陈瑞英,冷兴文,陶国枢.汉族和蒙古族维生素D受体基因多态性分布的研究[J].中国老年学杂志,2006,26(6):729-730. |
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| 作者姓名： | 张红红 牟小芬 孟秀梅 高宇红 刘建伟 吴青 胡亚卓 陈瑞英 冷兴文 陶国枢 |
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| 作者单位： | 1. 解放军总医院老年医学研究所,北京,100853
2. 兰州军区乌鲁木齐总医院 |
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| 摘 要： | 目的 分析中国汉族与蒙古族维生素D受体（VDR）基因多态性分布.方法 应用PCR-RFLP技术,分别对我国179名汉族和112名蒙古族健康绝经后妇女的VDR基因型进行分型,并计算其基因频率分布.结果 汉族和蒙古族绝经后妇女bb基因型频率分别为90.5%和50%,BB基因型频率分别为0%和4.46%,汉族与蒙古族之间VDR基因型频率分布差异非常显著（P＜0.001）.结论 我国汉族与蒙古族之间VDR基因型多态性具有种族差异性,这种种族差异性与骨质疏松的相关性有待于进一步研究.
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| 关 键 词： | 维生素D受体基因 遗传多态性 汉族 蒙古族 |
| 文章编号： | 1005-9202（2006）06-0729-02 |
| 收稿时间： | 2006-02-27 |
| 修稿时间： | 2006-03-27 |
Distribution of vitamin D receptor gene polymorphism in Han and Mongoloid nationality in China |
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| ZHANG Hong-Hong, MU Xiao-Fen, MENG Xiu-Mei,et al..Distribution of vitamin D receptor gene polymorphism in Han and Mongoloid nationality in China[J].Chinese Journal of Gerontology,2006,26(6):729-730. |
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| Authors: | ZHANG Hong-Hong MU Xiao-Fen MENG Xiu-Mei |
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| Institution: | Geriatrics Research Institute, General Hospital of Chinese PLA, Beijing 100853, China |
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| Abstract: | Objective To determine the distribution of vitamin D receptor (VDR) gene polymorphism in women of Han and Mongoloid nationality in China.Methods VDR genotypes of healthy postmenopausal women of 179 Han and 112 Mongoloid nationality were classified by polymerase chain reaction-restriction fragment length polymorphism to calculate genotype frequencies and distribution.Results For women of Han and Mongoloid nationality, the BB genotypes accounted for 0% and 4.46%, the bb genotypes accounted for 90.5% and 50% respectively (P<0.001). Conclusions There was a significant difference in VDR genotype between women of Han and Mongoloid nationality, which need further evidence on the different pathogeny of osteoporosis in various ethnic groups. |
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| Keywords: | Vitamin D receptor gene Genetic polymorphism Han nationality Mongoloid nationality |
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