| 胰岛素样生长因子基因在人淋巴结的表达与分布 |
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| 引用本文： | 巴建明,罗国春,潘长玉.胰岛素样生长因子基因在人淋巴结的表达与分布[J].中华内分泌代谢杂志,1998,14(3):180-182. |
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| 作者姓名： | 巴建明 罗国春 潘长玉 |
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| 作者单位： | 上海医科大学儿科医院 |
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| 摘 要： | 目的 观察胰岛素样生长因子（ Ｉ Ｇ Ｆｓ） ｍ Ｒ Ｎ Ａ 在人正常淋巴结的表达与分布，探讨 Ｉ Ｇ Ｆｓ与免疫系统功能的关系。方法 采用地高辛标记人 Ｉ Ｇ Ｆｓ １０ 个反义 Ｒ Ｎ Ａ 探针和原位杂交的方法。结果 发现 Ｉ Ｇ Ｆｓ 基因主要在淋巴结间质的网状细胞表达， Ｉ Ｇ Ｆ Ｉ、 Ｉ Ｇ Ｆ Ｂ Ｐ２ 和 Ｉ Ｇ Ｆ Ｂ Ｐ３ 阳性表达细胞在淋巴结较均匀的分布， Ｉ Ｇ Ｆ Ｉ Ｉ Ｒ 多分布于外皮质区， Ｉ Ｇ Ｆ Ｂ Ｐ４ 和 Ｉ Ｇ Ｆ Ｂ Ｐ５ ｍ Ｒ Ｎ Ａ 阳性表达多见于皮质深层。结论 在淋巴结 Ｉ Ｇ Ｆｓ 主要以旁分泌的形式产生，其对于免疫功能的维持可能具有重要意义。
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| 关 键 词： | 胰岛素样生长因子 基因 淋巴结 免疫功能 |
Expression and distribution of insulin like growth factors genes in human normal lymph nodes |
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| Yang Yi,Chen Lian,Zhang Hongzhi,et al..Expression and distribution of insulin like growth factors genes in human normal lymph nodes[J].Chinese Journal of Endocrinology and Metabolism,1998,14(3):180-182. |
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| Authors: | Yang Yi Chen Lian Zhang Hongzhi |
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| Institution: | Yang Yi,Chen Lian,Zhang Hongzhi,et al.Children's Hospital,Shanghai Medical University,Shanghai,200032 |
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| Abstract: | Objective To observe the expression and distribution of insulin like growth factors (IGFs) genes in human normal lymph nodes. Methods IGFs mRNA in lymph nodes were detected by in situ hybridization with Digoxin labeled IGFs riboprobes. Results Most of the IGFs genes were transcribed in reticular cells. IGF I, IGFBP2 and IGFBP3 mRNA were distributed all over the lymph nodes. IGF IIR was mainly expressed in the outer cortex. IGFBP4 and IGFBP5 mRNA expression cells were observed in deep cortex. Conclusion The data suggest that in lymph nodes IGFs are produced and function in a paracrine autocrine fashion. They may play an important role in maintenance of immune system functions. |
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| Keywords: | Insulin like growth factors Genes Lymph nodes Immune functions |
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