| 白介素-17、-23在结核性脑膜炎中的免疫致病机制探讨 |
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| 引用本文： | 程碧珍,杨礼,林诗扬,张俏忻,蔡应木. 白介素-17、-23在结核性脑膜炎中的免疫致病机制探讨[J]. 汕头大学医学院学报, 2014, 0(1): 33-34,37 |
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| 作者姓名： | 程碧珍 杨礼 林诗扬 张俏忻 蔡应木 |
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| 作者单位： | [1]汕头大学医学院第一附属医院检验科,广东汕头515041 [2]广州医科大学2010级临床医学系,广东广州510182 |
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| 基金项目： | 广东省自然科学基金资助项目（S2012010009081） |
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| 摘 要： | 目的：探讨白介素（IL）-17、-23在结核性脑膜炎（TBM）中的致病机制及其对TBM诊断和预后的意义。方法：用双抗体夹心法检测18例TBM患者（TBM组）血清及脑脊液（CSF）中IL-17、-23因子水平。并对IL-17、-23与TBM组CSF中各参数的相关性进行分析。结果：TBM组血清和CSF中IL-17水平分别为83.8±5.9和106.4±8.8;IL-23水平分别为103.1±7.1和172.8±8.3,与对照组比均有统计学意义（P〈0.01）。且IL-17、-23升高水平与TBM组CSF中的WBC数量正相关。结论：IL-17、-23在TBM的免疫致病机制中起着重要作用。
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| 关 键 词： | 结核性脑膜炎 白介素-17 白介素-23 |
The Pathological Mechanism of Interleukin-17,-23 in Tubercular Meningitis Patients |
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| CHENGBi-zhen,YANG Li,LINShi-yang,ZHANGQiao-xin,CAIYing-mu. The Pathological Mechanism of Interleukin-17,-23 in Tubercular Meningitis Patients[J]. Journal of Shantou University Medical College, 2014, 0(1): 33-34,37 |
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| Authors: | CHENGBi-zhen YANG Li LINShi-yang ZHANGQiao-xin CAIYing-mu |
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| Affiliation: | 1 Department of Clinical Laboratory, The First Ajfiliated Hospital, Shantou University Medical College, Shantou 515041, China, 2 Grade 2010, Department of Clinical Medicine, Guangzhou Medical University, Guangzhou 510182, China) |
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| Abstract: | Objective：To reveal the pathological mechanism and the prognostic value of interleukin-17,-23 in the tubercular meningitis（TBM）patients. Methods：Serum and CSF of 18 TBM patients were collected to detect IL-17,-23 with ELISA method. The relationship of IL-17,-23 changes with the parameters of CSF was analyzed by the pearson correlation. Results：IL-17,-23 levels in serum and CSF in the TBM group were 83.8±5.9 and 106.4±8.8,103.1±7.1 and 172.8±8.3, respectively. IL-17,-23 in the TBM group were higher than those the control group（P0.01）. IL-17,-23 had correlation with WBC numbers. Conclusion：IL-17,-23 may play important roles in pathological mechanism of TBM. |
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| Keywords: | tubercular meningitis interleukin-17 interleukin-23 |
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