| 遗传性非息肉病性结直肠癌 |
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| 引用本文： | 毛剑峰,董坚,陈明清.遗传性非息肉病性结直肠癌[J].国际肿瘤学杂志,2006,36(1):466-469. |
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| 作者姓名： | 毛剑峰 董坚 陈明清 |
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| 作者单位： | 昆明医学院附属第一医院生物治疗中心,650032; |
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| 摘 要： | Hereditary non-polyposis colorectal cancer(HNPCC) is an autosomal-dominantly inherited disease which is associated with germline mutations in mismatch repair(MMR) genes and microsatellite instability (MSI). As an important clinical subtype of colorectal cancer, HNPCC is accounting for 5%～15% of colorectal cancer. It' s focus research of colon cancer and hereditary tumor currently because of the special genetic etiopathogenisis and the prominent clinical pathology characteristic.
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| 关 键 词： | 遗传性非息肉性 结直肠肿瘤 碱基错配 微卫星不稳定 |
Hereditary non-polyposis colorectal cancer |
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| Abstract: | |
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| Keywords: | Hereditary nonpolyposisColorectal neoplasmsBase pair mismatchMicrosatellite instability |
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