| 皮质醇的动态变化与夜间哮喘发病机制研究 |
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| 引用本文： | 王晓芝,李云华,高福泉,李嘉文,牟爱芹,尚莉. 皮质醇的动态变化与夜间哮喘发病机制研究[J]. 滨州医学院学报, 2001, 24(1): 1-3 |
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| 作者姓名： | 王晓芝 李云华 高福泉 李嘉文 牟爱芹 尚莉 |
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| 作者单位： | 1. 滨州医学院附属医院呼吸内科
2. 烟台市北海医院 |
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| 基金项目： | 山东省教育厅资助项目;J97K08; |
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| 摘 要： | 目的 探讨皮质醇的动态变化与哮喘病人夜间加重或发作的关系。方法：检测夜间哮喘病人急性发作期、缓解期和健康对照组血浆中皮质醇早晨4时与下午4时含量的变化及与峰值流速 （PEF）变化的相关性。结果：从未用糖皮质激素治疗的急性发作期病人皮质醇的含量与健康对照组相比差异无显著性，缓解期病人的皮质醇含量较急性发作期和健康人明显减低，且缺乏动态变化规律。结论：从来用糖皮质激素治疗的哮喘病人有与健康对照组相同的糖皮质激素水平和昼夜变化节律，因此哮喘病人夜间加重不是由皮质醇水平降低而致，缓解期病人的皮质醇含量低及缺乏昼夜变化节律可能是全身应用皮质激素的结果。
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| 关 键 词： | 哮喘 皮质醇 动态变化 病理 |
| 文章编号： | 1001-9510(2001)01-0001-03 |
| 修稿时间： | 2000-07-25 |
STUDY ON RELATIONSHIP BETWEEN THE CIRCADIAN VARIATION OF CORTISONE AND THE PATHOGENESIS OF NOCTURNAL ASTHMA |
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| Wang Xiaozhi,Li Yunhua,Gao Fuquan,et al. STUDY ON RELATIONSHIP BETWEEN THE CIRCADIAN VARIATION OF CORTISONE AND THE PATHOGENESIS OF NOCTURNAL ASTHMA[J]. Journal of Binzhou Medical College, 2001, 24(1): 1-3 |
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| Authors: | Wang Xiaozhi Li Yunhua Gao Fuquan et al |
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| Abstract: | Objective:To explore the relationship between the circadian variation of cortisone and the pathogenesis of nocturnal asthma.Methods: Blood levels of cortisone and PEF were measured during acute exacerbation in 30 nocturnal asthmatic patients (not treated with glucocorticoid,during stabilization in 30 asthmatic ptaients,and at 4 AM and 4 PM in 30 normal control subjects.Results: There was normal level and circadian rhythm of cortisone during acute exacerbation in nocturnal asthmatic patients when compared with control group ( P >0 05).Conclusion:Nocturnal worsening symptoms of asthma could not be caused by reduction of serum cotisone concentration. |
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| Keywords: | circadian variation cortisone asthma |
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