金多靶对单纯性肥胖大鼠的减肥效果及机制探讨

目的：研究不同剂量金多靶对以胖大鼠的减肥效果及机制。方法：以单纯性肥胖大鼠的体重、Ｌｅｅ’ｓ指数、腹腔脂肪细胞总量、脂肪细胞大小、脂肪细胞瘦素表达（免疫组化，ＡＢＣ法）、血清瘦素（放免法）、血脂和血糖为指标，比较不同剂量金多靶灌服１个月（限制饮食）的减肥效果。结果：中等剂量（每天４０ｍｇ／１００ｇ体重）金多靶灌服１个月后大鼠减肥疗效产好。减肥同时血胆固醇及血糖有不同程度降低。减肥有效时脂肪细胞瘦素

Exploration of Weight-Reducing Effect of Kintop in Obese Rats and Its Mechanism

OBJECTIVE: To investigate the weight-reducing effect of Kintop and its probable mechanism in obese rats. METHODS: Body weight, Lee's index, total weight of celiac fat tissue, adipocyte size, blood glucose, blood lipid, expression of leptin in adipocyte (by ABC method), level of serum leptin (by RIA) of obese rats were chosen as the indexes to compare the weight-reducing effect of different dosages of Kintop. The administration of Kintop lasted 1 month. RESULTS: Good effect could be obtained by administration of medium dose Kintop (40 mg/100 g body weight per day) in simple obese rats. At the same time of reducing body weight, blood cholesterol and sugar levels also decreased in a certain degree. The adipocyte leptin expression reduced and serum leptin elevated in those rats with body weight reduced effectively by Kintop. CONCLUSION: Medium dose of Kintop administration for 1 month shows evident weight-reducing effect in simple obese rats, the effect might be related to raising the serum leptin level. Kintop also has the effect in lowering blood cholesterol level, and it could lower the blood sugar in obesity complicated with hyperglycemia by increasing the dosage appropriately.