| 矽肺发病机制与遗传易感性研究 |
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| 引用本文： | 曲亚斌,夏昭林. 矽肺发病机制与遗传易感性研究[J]. 职业卫生与应急救援, 2005, 23(4): 178-182 |
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| 作者姓名： | 曲亚斌 夏昭林 |
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| 作者单位： | 复旦大学公共卫生学院劳动卫生教研室,上海,200032 |
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| 摘 要： | 矽肺是矽尘暴露导致的职业性肺部疾患,它的发病机制至今尚未完全阐明.巨噬细胞相关细胞因子及其调节网络、细胞氧化应激损伤、信号转导和细胞凋亡通路、矽肺遗传易感性探索是目前研究的热点.该文简要回顾了近年来关于矽肺发病的细胞和分子机制的研究进展.
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| 关 键 词： | 矽肺 发病机制 遗传易感性 |
| 文章编号： | 1007-1326（2005）04-0178-05 |
| 收稿时间： | 2005-05-23 |
| 修稿时间： | 2005-08-12 |
Mechanisms in the Pathogenesis of Silicosis and Its Genetic Susceptibility |
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| QU Ya-bin,XIA Zhao-lin. Mechanisms in the Pathogenesis of Silicosis and Its Genetic Susceptibility[J]. Occupational Health and Emergency Rescue, 2005, 23(4): 178-182 |
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| Authors: | QU Ya-bin XIA Zhao-lin |
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| Affiliation: | Department of Occupational Health, School of Public Health, Fudan University, Shanghai 200032, China |
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| Abstract: | Silicosis is an occupational pulmonary disease caused by silica dust exposure, but the mechanisms of the injury and disease development are not well understood. Recent researches have mainly focused on macrophage-derived cytokines and their regulating network, cellular oxidative-stress injury, pathways of signal transduction and apoptosis, and genetic susceptibility of silicosis. In this review, we briefly introduce the research advances on molecular and cellular mechanisms in the pathogenesis of silicosis and its genetic susceptibility. |
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| Keywords: | silicosis pathogenesis genetic susceptibility |
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