| Abstract: | Peripheral lymph (afferent to the popliteal node) was collected from four sheep under physiological conditions. The concentration of protein in the lymph was never more than 20 per cent of that of the protein in the blood plasma. However, ultracentrifugal analysis showed that 19S macroglobulins accounted for 12 per cent of the globulins present in blood plasma but for only 4 per cent of the globulins in peripheral lymph. Thus, the concentration of macroglobulin in the lymph can be only about one-sixteenth of that in the blood. This was confirmed by titrating the amounts of both naturally occurring and induced 19S antibodies in blood and lymph. When inflammation was induced in the area of skin drained by the lymphatic fistula the titre of 19S antibodies in the lymph doubled. |
