高敏C-反应蛋白与白介素-6在急性冠状动脉综合征意义

目的 探讨急性冠状动脉综合征(acute coronary symptom,ACS)病人血清高敏C反应蛋白(high sensitivity-C reactive protein,hs-CRP)和白介素-6(interleukin-6,IL-6)浓度的变化及临床意义.方法 ACS组ACS病人60例,稳定型心绞痛(stable angina pectoris,SAP)组病人40例,对照组为40名健康人,检测血清IL-6、hs-CRP水平.结果 ACS组血清IL-6、hs-CRP水平明显高于SAP组和对照组(P＜0.01);ACS组中,急性心肌梗死病人又高于不稳定型心绞痛病人(P＜0.05);SAP组与对照组差异无统计学意义(P＜0.05);血清IL-6和hs-CRP水平呈正相关(r=0.5942,P＜0.01).结论 ACS病人血清IL-6和hs-CRP升高,其水平变化反映ACS的严重程度.

Clinical significance of the changes of serum high-sensitivity C-reactive protein and interleukin-6 levels in patients with acute coronary syndrome

Objectives To investigate the clinical significance of the changes of serum high-sensitivity C-reactive protein and interleukin-6 (IL-6) levels in patients with acute coronary syndrome (ACS). Methods The serum levels of IL-6 and hs-CRP were detected in 60 patients with ACS (ACS group), 40 patients with stable angina pectoris (SAP group) and 40 healthy subjects (control group). Results the serum levels of IL-6 and hs-CRP in ACS group were higher than those in SAP group and control group (P<0.01),among the patients with ACS,the serum IL-6 and hs-CRP levels in AMI patients were higher than those of UAP (unstable angina) group (P<0.05). There was no significant difference in the levels of IL-6 and hs-CRP between SAP group and control group (P>0.05). There was a positive correlation between IL-6 and hs-CRP levels(r=0.5942,P<0.01). Conclusions IL-6 and hs-CRP are correlated with pathogenesis of ACS and may reflect the severity of ACS.