11096例体检者幽门螺杆菌感染现状分析

目的 了解天津地区体检人群中幽门螺杆菌 （Hp） 感染的现状及其分布特征。方法 选取 2014 全年间在我院行 Hp 检测的 11 096 例体检者为研究对象， 应用快速尿素酶法检测其 Hp 的感染情况； 以体检者的性别、 年龄、职业为依据进行分组分析。结果 11 096 例体检者 Hp 总感染率为 30.52% （3 386/11 096）， 其中男性为 34.77% （1 784/5 131）， 女性为 26.86% （1 602/5 965）， 男性高于女性 （P < 0.05）； 将体检者按照年龄分为 19～29 岁、 30～39 岁、 40～49 岁、 50～59 岁、 60～69 岁和 70～92 岁组， 其 Hp 感染率分别为 19.50% （379/1 944）、 25.82% （650/2 517）、 31.59% （908/2 874）、 37.48% （915/2 441）、 41.09% （353/859） 和 39.18% （181/462）， 其中 50～59 岁、 60～69 岁和 70～92 岁组＞40～49 岁组＞30～39 岁组＞19～29 岁组 （P < 0.003）； 根据体检者职业不同进行分组研究， 在医务工作者、 工人、 教师、 工程师、 职员、 公务员、 其他等 7 个组中 Hp 感染率分别为 25.42% （586/2 305）、 29.35% （1 062/3 618）、 30.61% （360/1 176）、 32.49% （116/357）、 33.44% （205/613）、 34.52% （455/1 318） 和 35.23% （602/1 709）， 医务工作者 Hp 感染阳性率 25.42 （586/2 305） 低于工人、 教师、 职员、 公务员和其他人员各组 （P＜0.002）。结论 应加强中老年尤其是男性的 Hp 诊疗管理， 普及 Hp 感染预防相关医学知识， 从而更有效地预防 Hp 感染相关疾病的发生。

Pylori infection distribution in 11 096 individuals

Abstract: Objective To investigate the distribution of Helicobacter pylori (Hp) infections among general population in Tianjin. Methods Individuals (n=11 096) who visited our hospital for medical examination and H. Pylori infection screen were included in the research objects. Rapid urease method was utilized to rapidly detect H. pylori infection among the popultion. Individuals were grouped based on their gender, age and occupations, and then were analyzed. Results H. pylori-positive rate was 30.52% (3 386/11 096) in 11 096 individuals, in which there were 34.77% (1 784/5 131) male and 26.86% (1 602/5 965) female respectively. Individuals were divided into 5 groups according to their ages: 19 to 29 years old group, 30 to 39 years old group, 40 to 49 years old group, 50 to 59 years old group, 60 to 69 years old group and 70 to 92 years old group. The positive rates of H. pylori increased with age: 19.50% ( 379/1 944 ) in 19-29 years old group, 25.82% (650/2 517 ) in 30-39 years old group, 31.59% ( 908/2 874 ) in 40-49 years old group, 37.48% (915/2 441 ) in 50-59 years old group, 41.09% ( 353/859 ) in 60-69 years old group and 39.18% (181/462) in 70-92 years old group. The differences in positive rates between different age groups were all of statistically significant (P < 0.05). Individuals were also divided into seven groups according to their occupations: medical worker group, worker group, teacher group, engineer group, clerk group, civil worker group and other career group. The positive rates of H. pylori infection were 25.42% （586/2 305） , 29.35% （1 062/3 618） , 30.61% （360/1 176） , 32.49% （116/357） , 33.44% （205/613） , 34.52% （455/1 318） and 35.23% （602/1 709） respectively. The positive rate was 25.42% (586/2 305) medical workers, which was lower than that of other occupation groups with significant difference (P < 0.002). Conclusion Good management of H. pylori diagnosis and treatment in mid⁃ dle age and elderly together with popularizing knowledge of H.pylori prevention can effectively reduce H.pylori incidence.