Open trial of nefazodone for combat veterans with posttraumatic stress disorder |
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Authors: | Garfield D A Fichtner C G Leveroni C Mahableshwarkar A |
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Affiliation: | (1) Department of Psychiatry and Behavioral Sciences, Finch University of Health Sciences/The Chicago Medical School, North Chicago, Illinois;(2) Veterans Affairs Medical Center, North Chicago, Illinois;(3) Illinois Department of Human Services, Illinois |
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Abstract: | Fourteen combat veterans completed a 9-week open trial of nefazodone for treatment of posttraumatic stress disorder (PTSD). Overall PTSD symptoms as measured by the Clinician-Administered PTSD Scale (CAPS) showed a modest but statistically significant decrease with nefazodone treatment. Decreases in CAPS reexperiencing and avoidance, but not hyperarousal symptoms, approached statistical significance. Anxiety decreased significantly, and there were trends toward decreased depression and anger on structured assessments. This study adds to the clinical evidence that nefazodone may be helpful for the management of PTSD symptoms. |
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Keywords: | nefazodone PTSD combat veterans antidepressant or psychotropic medication anxiety depression anger |
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