促血管生成素-2在子宫内膜异位性疾病中的表达及其意义

目的检测促血管生成素-2（Ang-2）在子宫内膜异位性疾病患者在位及异位内膜中的表达，并探讨其在子宫内膜异位性疾病发病的作用。方法应用逆转录聚合酶链反应（RT—PCR）技术检测Ang-2mRNA在65例子宫内膜异位症患者（内异症组）、40例子宫腺肌病患者（腺肌病组）的异住及在位内膜中的表达及在30例正常子宫内膜组织（对照组）中的表达。结果内异症组及腺肌病组的异位及在位内膜中Ang-2的表达率均高于对照组，但其表达强度与子宫内膜异位症的临床分期无明显相关性。结论子宫内膜异位症及子宫腺肌病患者的异位及在位内膜组织中Ang-2的表达增强，Ang-2在子宫内膜异位性疾病的发病过程中起到一定的促进作用。

Expression of angiopoietin-2 mRNA and its significance in endometriosis and adenomyosis

[Objective] To determine the expression of angiopoietin-2 (Ang-2) in eutopic and ectopic endometrium of endometriosis and adenomyosis, and to investigate the role of it in the pathogenesis of endometriosis and adenomyosis. [Methods] Expression of Ang-2 mRNA in the eutopic and ectopic endometrium of 65 patients with endometriosis (endometriosis group) and 40 patients with adenomyosis (adenomyosis group) and the expression of Ang-2 mRNA in the normal endometrium of 30 patients (control group) without endometriosis and adenomyosis were detected by RT-PCR. [Results] Expression levels of Ang-2 mRNA in the eutopic and ectopic endometrium with endometriosis and adenomyosis were significantly higher than that in control group, and there was not significant relevance between the expression level and the clinical staging. [Conclusion] Expression of Ang-2 mRNA has a high level in the eutopic and ectopic endometriotic tissues with endometriosis and adenomyosis. Ang-2 may play a very important role in the development of endometriosis and adenomyosis and may relate to the pathogenesis of endometriosis and adenomyosis.