Transcatheter thrombolysis in cancer patients |
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| Authors: | Sho Kudo Vincent P. Chuang M.D. Sidney Wallace Sylvia Mir William Bechtel C. Humberto Carrasco |
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| Affiliation: | (1) Department of Diagnostic Radiology, The University of Texas, M. D. Anderson Hospital and Tumor Institute at Houston, Texas, USA;(2) Present address: Department of Radiology, Faculty of Medicine, Kuyshu University, Maidashi, Higashi-ku, Fukuoka, Japan;(3) Present address: Department of Radiology, Emory University Hospital, 1365 Clifton Road, 30322 Atlanta, Georgia, USA |
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| Abstract: | Arterial thrombolysis was successfully accomplished in 15 of 18 (83%) cancer patients by the continuous intraarterial transcatheter administration of streptokinase (70 units/kg/h or 5000 u/h and/or urokinase (400–500 u/kg/h) over 24–96 h. In 16 of these patients, the arterial thrombosis was a complication of transcatheter infusion of chemo-therapeutic agents or embolization therapy. A combination of streptokinase, urokinase and heparin (10,000–25,000 U/day) was utilized without significant side effect and was effective in all 8 patients receiving treatment. Creating a tunnel through the clot, daily monitoring of the catheter with repositioning when necessary, and adjusting the type and dose of thrombolytic agent aided the therapeutic management. |
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| Keywords: | Streptokinase infusion Urokinase Cytostatic infusion, intraarterial Thrombosis, arterial Transcatheter thrombolysis Catheters and catheterization, complications Chemotherapy, intraarterial |
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