N-MYC下游调节基因-2蛋白在前列腺肿瘤组织中的表达

【目的】N-MYC下游调节基因-2(NDRG2)在前列腺癌及前列腺增生中的表达与临床病理特征和生物学行为的关系【方法】前列腺肿瘤标本51例,其中前列腺增生标本9例,前列腺癌标本42例,均为存档石蜡切片,应用免疫组织化学(S-P法)研究NDRG2表达。【结果】NDRG2在前列腺增生组织表达为82.35%,在前列腺癌组织为32.69%,两者差异有统计学意义(P<0.01)。NDRG2表达水平同Gleason评分呈负相关(r=-0.5197),在不同临床TNM分期间、在血清PSA浓度≤20 ng/ml与PSA浓度>20 ng/ml组间差异无统计学意义(P>0.05)。【结论】NDRG2表达在前列腺癌组织低于前列腺增生组织,且表达与Gleason评分呈负相关。表明NDRG2有可能参与了前列腺癌的发生及发展过程。

Analysis of the N-MYC down-stream regulate gene-2 protein expression in prostatic carcinoma tissues

【Objective】To study the expression of N-MYC down-stream regulated gene-2（NDRG2）,a new candidate tumor suppressor,in prostate cancer,and to investigate its clinical and pathological implications.【Methods】Formalin-fixed,paraffin-embedded tissue sections from 42 cases of prostatic carcinoma（PCa） and 9 cases of benign prostate hyperplasia（BPH） were analyzed retrospectively with immunohistochemistry（S-P method）.【Results】The NDRG2 gene was highly expressed in benign prostatic hyperplasia tissues,but not in carcinomatous ones.Positive expression of NDRG2 proteins was detected in 14 of the 17（82.35%） benign tumor samples and accounted for 32.69% in prostatic carcinoma ones.Furthermore,positive expression of NDRG2 in prostatic carcinoma samples decreased significantly with the increasing of the gleason score（r =-0.5197）.However,positive expression of NDRG2 was not correlated with TNM tumor stages or the concentration of prostate-specific antigen（PSA）in blood serum（P0.05）.【Conclusion】The NDRG2 expression level was lower in PCA than in BPH.NDRG2 may play an essential role in prostate carcinogenesis and in the progress of PCA.