| 不同剂量红景天苷在大鼠体内的药动学研究 |
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| 引用本文： | 刘晓晖,张莉,胡建华,陈莉. 不同剂量红景天苷在大鼠体内的药动学研究[J]. 武警医学, 2011, 22(3): 231-233,236 |
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| 作者姓名： | 刘晓晖 张莉 胡建华 陈莉 |
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| 作者单位： | 330001,南昌,武警江西总队医院检验科;300162,天津,武警医学院药剂学教研室;武警医学院药剂学教研室,天津,300162;武警江西总队医院检验科,南昌,330001 |
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| 摘 要： | 目的 研究不同剂量红景天苷在大鼠体内的药动学.方法 采用RP-HPLC内标法测定大鼠尾静脉注射不同剂量红景天苷(15、30、60 mg/kg)后血清中的药物浓度.比较不同给药剂量下,红景天苷的血药浓度-时间曲线图及其经3P97程序处理所得的药动学参数.结果 根据药动学房室模型的判断方法,初步判定大鼠静脉注射后红景天苷在体内的过程符合二室模型.在低、中、高给药剂量下红景天苷的分布半衰期(T1/2α)分别为4.96、2.01和4.36 min,消除半衰期(T1/2α)分别为24.24、19.40和16.88 min.C0、AUC0-t 和AUC0-∞随着剂量的增加均呈线性增加,其中AUC0-t和AUC0-∞分别为362.15、879.77、1421.48 (μg·min)/ml和383.09、884.52、1426.63 (μg·min)/ml.结论 红景天苷给药剂量在15～60 mg/kg范围内,其药动学行为呈线性关系,未显现出药动学差异.
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| 关 键 词： | 红景天苷 药物动力学 剂量 静脉注射 HPLC |
| 收稿时间： | 2010-08-19 |
A study of pharmacokinetics of salidroside in rats at different doses |
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| LIU Xiaohui,ZHANG Li,HU Jianhua,CHEN Li. A study of pharmacokinetics of salidroside in rats at different doses[J]. Medical Journal of the Chinese People's Armed Police Forces, 2011, 22(3): 231-233,236 |
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| Authors: | LIU Xiaohui ZHANG Li HU Jianhua CHEN Li |
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| Affiliation: | LIU Xiaohui~(1,2),ZHANG Li~2,HU Jianhua~2,and CHEN Li~1.1.Department of Clinical Laboratory,Jiangxi Provincial Corps Hospital of Chinese People's Armed Police Forces,Nanchang 330001,China,2.Department of Pharmaceutics,Medical College of Chinese People's Armed Police Forces,Tianjin 300162 |
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| Abstract: | Objective To study the kinetic parameters of salidroside in rats after intravenous administration of different doses of salidroside.Methods The serum concentration of salidroside was analyzed by reversed - phase high - performance liquid chroma-tography (RP - HPLC)and the pharmacokinetic parameters were calculated by 3P97 following a single intravenous administration of salidroside at doses of 15,30,60 mg/kg in rats.Results The concentration - time data showed the characteristics of a two - compartment mode... |
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| Keywords: | HPLC |
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