盐酸米诺环素对慢性牙周炎基质金属蛋白酶-8水平的影响

 目的 研究盐酸米诺环素对慢性牙周炎患者龈沟液中基质金属蛋白酶-8(matrix metalloproteinase-8,MMP-8)水平的影响.方法 选26例中重度慢性成人牙周炎患者,每例口腔左右两个象限随机分为实验组和对照组.基础治疗后实验组使用盐酸米诺环素缓释软膏,每周1次,共2次.对照组不使用盐酸米诺环素软膏,仅使用生理盐水和10%过氧化氢冲洗.使用酶联免疫法(ELISA)测定两组治疗前后龈沟液中基质金属蛋白酶-8的水平.结果 实验组、对照组在基础治疗后龈沟液中基质金属蛋白酶-8总量和浓度均明显降低(P<0.01).实验组与对照组龈沟液中基质金属蛋白酶-8总量和浓度的变化差异有统计学意义,实验组基质金属蛋白酶-8总量和浓度减少的量要多于对照组(P<0.01).结论 基础治疗和盐酸米诺环素缓释软膏联合应用能有效降低慢性牙周炎患者龈沟液中基质金属蛋白酶-8水平,改善牙周状况.

Effect of Minocycline Hydrochloride Ointment on MMP-8 in Gingival Crevicular Fluid Abstract

Objective To analyze the changes of matrix metalloproteinases -8(MMP -8) levels in gingival crevicular fluid (GCF) after subgingivally administering 2%minocycline - HC1 ointment to the periodontal pocket as an auxiliary treatment of moderate and severe chronic periodontitis.Methods Twenty - six subjects were selected.The left and right sides of oral cavity were divided into control group and test group with a randomized single blind method.After initial periodontal treatment of both groups,the test group wa...