肥胖儿童白细胞计数与糖脂代谢及心血管危险因素的关系

目的:探讨肥胖儿童白细胞计数(WBCC)与糖脂代谢及心血管危险因素的关系。方法:收集我院儿科内分泌门诊8～15岁肥胖儿童111例,其中男84例,女27例。将WBCC分为WBCC1、WBCC2、WBCC3和WBCC4共4层,分别比较男孩、女孩各组糖脂代谢指标。对年龄及体质量指数(BMI)进行校正后采用偏相关分析不同性别儿童WBCC与糖脂代谢及心血管危险因素的关系,多元逐步回归分析影响WBCC水平的因素。结果:男孩WBCC、BMI、腰围(WC)及三酰甘油(TG)高于女孩,而收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、HOMA-IR及致动脉粥样硬化指数(AI)差异无统计学意义(P>0.05)。男孩及女孩的WBCC4组WC及BMI均高于WBBC1组,男孩WBCC4组TG及AI高于WBCC1组,WBCC4组的HDL-C低于WBCC1、WBCC2组(P<0.05)。男孩WBCC与BMI、WC、TG及AI呈正相关(P<0.05);女孩WBCC与BMI及WC呈正相关(P<0.05)。TG、WC、HDL-C为影响WBCC的因素。结论:WBCC与肥胖儿童中心性肥胖、血脂异常及糖代谢紊乱关系密切,早期检测WBCC水平并给予早期干预,可成为防止心血管疾病发生的简单、有效措施。

Correlation between White Blood Cell Count,Glucose and Lipid Metabolism and Cardiovascular Risk Factors in Obese Children

Objective:To investigate association of white blood cell count(WBCC) with glucose and lipid metabolism and cardiovascular risk factors in obese children.Methods:A total of 111 subjects,84 boys and 27 girls,aged 8-15 years were enrolled.The subjects were divided into four quartiles according to WBCC(WBCC 1-4,from the lowest to highest WBCC) in both genders.The mean values of glucose and lipid metabolism and cardiovascular risk factors were compared in boys and girls separately for each group.Bivariate correl...