| 基因多态性与胃癌化疗敏感性的研究进展 |
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| 引用本文： | 郑磊贞,王志杰.基因多态性与胃癌化疗敏感性的研究进展[J].上海交通大学学报(医学版),2011,31(1):89-94. |
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| 作者姓名： | 郑磊贞 王志杰 |
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| 作者单位： | 1. 上海交通大学医学院附属新华医院肿瘤科,上海,200092
2. 第二军医大学附属长征医院肿瘤科,上海,200003 |
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| 摘 要： | 药物化疗是胃癌抗肿瘤治疗的重要手段,氟尿嘧啶类和铂类药物是胃癌化疗的常规用药,但相同药物对不同患者往往产生不同的疗效,因此确定药物疗效的影响因素对于提高化疗效果至关重要。该文结合国内外化疗敏感性研究的最新进展,系统综述了氟尿嘧啶类和铂类等药物相关基因多态性与胃癌化疗敏感性研究的关系,以期为胃癌个体化治疗提供依据。
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| 关 键 词： | 胃癌 化疗敏感性 多态性 |
Research progress of gene polymorphisms and chemosensitivity for gastric cancer |
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| ZHENG Lei-zhen,WANG Zhi-jie.Research progress of gene polymorphisms and chemosensitivity for gastric cancer[J].Journal of Shanghai Jiaotong University:Medical Science,2011,31(1):89-94. |
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| Authors: | ZHENG Lei-zhen WANG Zhi-jie |
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| Institution: | 1.Department of Oncology,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China;2.Department of Oncology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China) |
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| Abstract: | Chemotherapy plays an important role in the treatment of gastric cancer, with fluorouracil and platinum being the common drugs. However, patients respond differently to the same drugs, the mechanism of which may be important to be clarified to improve the efficacy of chemotherapy. This review systematically highlights the relationship between gene polymorphisms and chemosensitivity for gastric cancer according to the latest studies, which may provide evidences for the personalised treatment for gastric cancer. |
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| Keywords: | gastric cancer chemosensitivity polymorphisms |
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