小剂量硫酸镁联合口服利托君在早产治疗中的应用

目的探讨小剂量硫酸镁静滴联合口服利托君在治疗早产中的临床应用价值。方法将早产治疗病例360例分为3组：A组采用常规剂量硫酸镁静滴，B组采用常规剂量利托君静滴，C采用小剂量硫酸镁静滴＋口服利托君联合治疗分别治疗不同孕周的早产。观察3组在抑制宫缩、延长孕周、孕妇副反应、新生儿预后等方面的效果。结果在抑制宫缩方面，治疗组B组效果最好，C组次之，A组最差，在降低早产率上，B组与C组均明显高于A组，P〈0．01，而B组与C组之间无差异，P〉0．05；在停药率上，A组为1例，C组为0例，而B组停药率为25％，显著高于A组和C组，P〈0．01。新生儿出生后转NICU率方面，A组与B组和C组比较，其新生儿转NICU的比例最多，P〈0．01，而B组与C组之间无差异（P〉0．05）。结论小剂量硫酸镁＋口服利托君联合用药在治疗早产中的疗效肯定。能有效降低早产率，且副作用少，适合临床推广。

Combination of low dose of Magnesium Sulfate and Ritodrine per os for preterm labor

Objective To value effect of the combination of low dose of Magnesium Suffate（MgSO4） and Ritodrine per os for preterm labor. Methods 360 patients in pretem labor at 28-36 weeks＇ gestation were randomly divided into three groups： A group are received MgSO4 intravenously only, B group was received ritodrine intravenously only, C group was received low dose of MgSO4 plus ritodrine per os. Four aspects： Inhibition of contraction, prolongation of gestation, reduction of side effect and decrease of rate of NICU were investigated. Results B group was the best in inhibiting contraction, better than A group（P〈0.01）, and C group better than A group as well（P〈0.01）. There were significantly decrease on the rate of premature birth and NICU in B and C group than A group （P〈0.01）. But the side effect of B group was significantly more than others. Conclusion Combination of MgSO4 and ritodrine was efficacious and safe from preterm labor.