| 四例伴t(3;3)的急性髓系白血病的临床和实验室分析 |
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| 引用本文： | 陈志妹,吴建国,金洁,楼基余,林茂芳.四例伴t(3;3)的急性髓系白血病的临床和实验室分析[J].中华血液学杂志,2004,25(1):35-37. |
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| 作者姓名： | 陈志妹 吴建国 金洁 楼基余 林茂芳 |
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| 作者单位： | 1. 310003,杭州,浙江大学医学院附属第一医院、浙江大学血液病研究所
2. 浙江省人民医院检验科 |
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| 基金项目： | 国家 8 63计划资助项目 (2 0 0 1AA2 2 70 71)，浙江省科技厅重点项目 (2 0 0 3C2 3 0 13 ) |
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| 摘 要： | 目的 探讨伴t(3;3)的急性髓系白血病 (AML)的临床和实验室特征。方法 骨髓细胞直接法和 2 4h短期培养法制备染色体 ,用R显带技术进行细胞遗传学分析。结果 4例患者的染色体核型分析结果均有t(3;3)的异常 ,临床和血液学改变符合AML诊断。 4例化疗后均未获得完全缓解 ,中位生存期为 4 .5个月。结论 t(3;3)是一种少见的核型异常 ,多存在于髓系白血病 ,其临床预后差。
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| 关 键 词： | 易位(遗传学) 白血病 粒细胞 急性 骨髓增生异常综合征 |
| 修稿时间： | 2003年6月9日 |
Clinical and laboratory investigation of four acute myeloid leukemia patients with t(3;3) translocation |
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| Zhi-mei Chen,Jian-guo Wu,Jie Jin,Ji-yu Lou,Mao-fang Lin.Clinical and laboratory investigation of four acute myeloid leukemia patients with t(3;3) translocation[J].Chinese Journal of Hematology,2004,25(1):35-37. |
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| Authors: | Zhi-mei Chen Jian-guo Wu Jie Jin Ji-yu Lou Mao-fang Lin |
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| Institution: | The First Affiliated Hospital of Medical College of Zhejiang University, Institute of Hematology, Hangzhou 310003, China. |
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| Abstract: | Objective To investigate the clinical and laboratory characteristics of four acute myeloid leukemia with t(3;3) translocation. Methods Bone marrow cell chromosome karyotype analysis were carried out with direct method and short-term culture and R-banding technique. Results Four AML patients with t(3;3) translocation were identified. They did not obtain complete remission after chemotherapy and the median survival time was 4.5 months. Conclusions t(3;3) translocation is a rare chromosome abnormality,which has mostly been found in myeloid leukemia and the prognosis of these patients is poor. |
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| Keywords: | Translocation Leukemia myeloid acute Myelodysplastic syndrome |
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