D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients |
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Authors: | Yan Zhang Minmin Zhang Tianhua Niu Xin Xu Guoying Zhu Yong Huo Changzhong Chen Xiaobin Wang Houxun Xing Shaojie Peng Aiqun Huang Xiumei Hong Xiping Xu |
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Affiliation: | (1) Department of Cardiology, Peking University First Hospital, Beijing, 100034, China;(2) Program for Population Genetics, Harvard School of Public Health, 665 Huntington Ave., FXB-101, Boston, MA 02115, USA;(3) School of Life Science, University of Science and Technology in China, Hefei, China;(4) Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA;(5) The Mary Ann and J. Milburn Smith Child Health Program, Children s Memorial Hospital and Children s Memorial Institute for Education and Research (CMIER), Chicago, IL 60614, USA;(6) Institute of Biomedicine, Anhui Medical University, Hefei, China |
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Abstract: | Individual variation in drug response is considered to have multiple origins arising from interactions among susceptible genes and environmental factors. A total of 726 hypertensive patients who took benazepril 10 mg once a day for 15 days and their families from Huoqiu county of Anhui Province, China, were used to study the association between D919G polymorphism of methionine synthase (MTR) gene and the antihypertensive effect of this angiotensin-converting enzyme inhibitor. Compared to the 919D allele, both population-based (P=0.010) and family-based association tests (additive model P=0.018, dominant model P=0.025) demonstrated that the 919G allele was associated with a significantly less diastolic blood pressure reduction. No significant association was found between the extent of systolic blood pressure reduction and benazepril therapy. Our finding suggests that the D919G polymorphism of the MTR gene may be a useful genetic marker to predict the antihypertensive effect of short-term benazepril therapy in hypertensive patients of Anhui Province, China. |
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Keywords: | Methionine synthase Polymorphism Hypertension Blood pressure Benazepril |
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