短程间歇化疗方案治疗初治涂阳肺结核效果研究

目的研究短程间歇化疗方案的有效性和安全性,探索结核病有效安全的防治用药方案。方法随机抽取初治涂阳病例100例,分为观察组（2H3R3Z3E3/4H3R3）和对照组（2HRZE/4HR）各50例。对两组病人的治疗效果、不良反应进行分析比较。结果观察组和对照组2月末痰菌阴转率分别为88.00%、91.84%,满疗程痰菌阴转率提高到98.00%、100%,两组2月末和满疗程X线胸片有效率分别为90.00%、93.88%和96.00%、100%,满疗程空洞闭合率为58.06%、65.38%,痰菌阴转率、X线胸片吸收率和空洞闭合率均无显著性差异（P〉0.05）;观察组和对照组临床不良反应率分别为12.00%和8.16%,WBC异常率分别为38.00%和30.61%,ALT异常率分别为18.00%和8.16%,两组均无显著性差异（P〉0.05）。结论短程间歇化疗方案与每日用药方案治疗效果相同,不良反应相似,但用药次数减少,具有一定的推广应用前景。

Results of intermittent shot course chemotherapy in treatment of smear-positive pulmonary tuberculosis

Objective To observe the effects and safety of intermittent short-course chemotherapy in treatment of tuberculosis and explore anti-tuberculosis chemotherapy suitable in Wenzhou.Methods One hundred new smear-positive pulmonary tuberculosis prtients were randomiy selected and allocated into treatment group consissted of 50 cases and control group also consisted of 50 cases.The results of treatment and side effects were in the two grous were compared.Results The sputum negative conversion rate two months after treatment in the treatment group and the controlled group were 88.00% and 91.84% and 98.00% and 100% six months after treatment.The cavity closure rates six month after treatment in the treatment group anf control group were 58.06% and 65.38%.The rates of adverse reaction,abnormality of WBC and ALTin the treatment group were 12.00%,38.00% and 18.00%,while in the control group were 8.16%,30.61% and 8.16%,without significantly statistical difference between the two groups（P〉0.05）.Conclusion The effect and adverse reaction of intermitteant short-course chemotherapy are similar to that of daily short-course chemotherapy in traeting new smear-positive tuberculosis patients,but with less times of drug administration.Thus can be popularized in practical treatment.