tPA和PAI-1活性与自然流产的相关性

【目的】探讨组织型纤溶酶原激活剂（tPA）和纤溶酶原激活剂抑制剂-1（PAI-1）活性与自然流产的相关性。【方法】选择2003年10月至2004年3月中南大学湘雅二医院门诊有自然流产史患者71例（非孕50例．孕妇21侧）和对照组41例（非孕20侧，孕妇21例）进行研究，运用发色底物法测定血浆tPA和PAI-1活性。【结果】非孕有自然流产史的研究组tPA活性比对照组低（t=2．226，P=0．029〈0．05），早孕研究组tPA活性比对照组低（t=2．166，P=0．036〈0．05），差别均有统计学意义；研究组中，tPA活性早孕高于非孕（t=-2．937，P=0．005），PAI-1活性早孕低于非孕（t=2．428，P=0．018）；在对照组中，tPA活性早孕也高于非孕（t=2．597，P=0．013），PAI-1活性早孕也低于非孕者（t=2．653，P=0．012）。差别均有统计学意义。【结论】妊娠后tPA活性增高和PAI-1活性下降。有自然流产史者在非孕状态时tPA活性明显下降，且妊娠后呈低增长水平。tPA活性下降与引起自然流产的发病机制有关。

The Relativity Among Tissue-type Plasminogen Activator (tPA), Plasminogen Activator Inhibitor Type 1 (PAI-1) Activity and Spontaneous Abortion

[Objective]To study the relativity among the tissue-type plasminogen activator (tPA), plasminogen activator inhibitor type 1(PAI-1) activity and spontaneous abortion.[Methods]Candidates came from the Second Xiangya Hospital of Central South University, including the pregnant or non-pregnant women with(71 cases) and without(41 cases) the history of spontaneous abortion. Chromogenic assay was used to detect tPA and PAI-1 activity in plasma. [Results]The plasma tPA activity of women with the history of spontaneous abortion was statistically significantly lower than controls among the non-pregnant (t=2.226,P=0.029)and early pregnant women(t=2.166,P=0.036). The t-PA activity of the early pregnant was higher than that of the non-pregnant among the women with(t=-2.937, P=0.005) and without (t=2.597,P=0.013) the history of spontaneous abortion. The PAI-1 activity of early pregnant was lower than that of the non-pregnant among the women with (t=2.428,P=0.018) and without (t=2.653, P=0.012) the history of spontaneous abortion.[Conclusion] During pregnancy the t-PA activity increases. PAI-1 activity decreases. The t-PA activity decreases during non-pregnant period and increases to lower level after pregnancy among the women with the history of spontaneous abortion. The decreased t-PA activity is associated with pathogenesis of spontaneous abortion.