ATTEMPTS TO RECOVER HERPES SIMPLEX VIRUS FROM SKIN SITES OF RECURRENT INFECTION |
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| Authors: | EDGAR B. SMITH M.D. LEROY C. McLAREN Ph.D. |
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| Affiliation: | From the Division of Dermatology and Department of Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico |
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| Abstract: | ABSTRACT: We attempted to recover herpes simplex virus from the cutaneous sites of recurrent infections by co-cultivating explants of skin with monolayers of herpes virus susceptible cell lines. We were unable to demonstrate virus in the asymptomatic skin with this technique. Efforts to activate repressed virus in 2 patients by pretreatment of cultures with 5-iodo-2-deoxyuridine and application of the indirect fluorescent antibody technique to skin from 3 patients also failed to reveal evidence of herpesvirus. Our results support the concept that latent herpesvirus resides in nerve tissue but not skin. |
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