Early outcomes of alcohol septal ablation for hypertrophic obstructive cardiomyopathy |
| |
| Authors: | Josef Veselka MD PHD Thorsten Lawrenz MD Christoph Stellbrink MD David Zemanek MD PHD Marian Branny MD Jaroslav Januska MD Jan Sitar MD Pawel Dimitrow MD PHD Jan Krejci MD PHD Maciej Dabrowski MD PHD Stanislav Mizera MD Thomas Bartel MD Horst Kuhn MD |
| |
| Institution: | 1. Department of Cardiology, 2nd Medical School, Charles University and University Hospital Motol, Prague, Czech Republic;2. Klinikum Bielefeld‐Mitte, Department of Cardiology and Internal Intensive Care, Bielefeld, University of Witten/Herdecke, Germany;3. Department of Cardiology, University of Witten/Herdecke, Germany;4. 1st Department of Internal Medicine/Cardioangiology, International Clinical Research Centre–St. Anne's University Hospital, Brno, Czech Republic;5. Department of Cardiology, Podlesi Hospital, Trinec, Czech Republic;6. Department of Cardiology, Varna, Bulgaria;7. 2nd Department of Cardiology, Collegium Medicum, Jagiellonian University, Cracow, Poland;8. Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland;9. Department of Cardiology, National Institute of Cardiovascular Diseases, Bratislava, Slovakia;10. Department of Internal Medicine III, Medical University Innsbruck, Austria |
| |
| Abstract: | Background: This study was designed to evaluate the outcomes of alcohol septal ablation (ASA) under multicenter and multinational conditions. Methods: Data for 459 patients (age 57 ± 13 years) from nine European centers were prospectively collected and retrospectively analyzed. Results: ASA led to a significant reduction in outflow gradient (PG) and dyspnea median of PG from 88 (58–123) mm Hg to 21 (11–41) mm Hg; median of NYHA class from 3 (2–3) to 1 (1–2); P < 0.01]. The incidence of 3‐month major adverse events (death, electrical cardioversion for tachyarrhythmias, resuscitation) and mortality was 2.8% and 0.7%, respectively. Permanent pacemakers for post‐ASA complete heart block were implanted in 43 patients (9%). Multivariate analysis identified higher amount of alcohol (however, in generally low‐dose procedures), higher baseline left ventricular ejection fraction and higher age as independent predictors of PG decrease ≥50%. Conclusions: The results of the first European multicenter and multinational study demonstrate that real‐world early outcomes of ASA patients are better than was reported in observations from the first decade after ASA introduction. © 2013 Wiley Periodicals, Inc. |
| |
| Keywords: | hypertrophic cardiomyopathy alcohol septal ablation cardiomyopathy |
|
|
