| 紫杉醇对人腺样囊性癌细胞株ACC-2体外辐射增敏作用 |
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| 引用本文： | 施斌,林李嵩,陈乃俊,张纬建,林耿冰,朱小峰. 紫杉醇对人腺样囊性癌细胞株ACC-2体外辐射增敏作用[J]. 福建医科大学学报, 2004, 38(3): 275-278 |
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| 作者姓名： | 施斌 林李嵩 陈乃俊 张纬建 林耿冰 朱小峰 |
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| 作者单位： | 1. 福建医科大学,附属第一医院,口腔颌面外科,福州,350005
2. 福建医科大学,附属第一医院,放疗科,福州,350005 |
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| 基金项目： | 福建省教育厅科研基金资助项目 ( K0 2 0 73 ) |
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| 摘 要： | 目的 评价紫杉醇对人腺样囊性癌细胞株ACC-2的辐射增敏作用。方法 用克隆形成法检测不同时间-浓度条件紫杉醇和／或放射作用后的人腺样囊性癌细胞株ACC-2细胞存活分数，计算辐射增敏率(SER)。结果 紫杉醇对ACC-2细胞具有体外增殖抑制作用。人腺样囊性癌细胞株ACC-2的平均效应剂量(Do)=1．43Gy，Dq=3．6Gy，10，100，1000nmol紫杉醇作用24h后SER分别为1．29，1．66和1．23。结论 人腺样囊性癌细胞株ACC-2具有一定的辐射抗性。紫杉醇对其体外增殖抑制作用表现为时间．浓度依赖性效应。一定条件下紫杉醇对人腺样囊性癌细胞株ACC-2具有辐射增敏作用。
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| 关 键 词： | 癌，腺样囊性 紫杉酚 辐射增敏药 肿瘤细胞 培养的 |
| 文章编号： | 1672-4194(2004)03-0275-04 |
| 修稿时间： | 2004-03-29 |
Radiosensitizing Enhancement Effect of Paclitaxel on Human Adenoid Cystic Carcinoma ACC-2 Line Cell in vitro |
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| SHI Bin ,LIN Li song ,CHEN Nai jun ,ZHANG Wei jian ,LIN Geng bin ,ZHU Xiao feng. Radiosensitizing Enhancement Effect of Paclitaxel on Human Adenoid Cystic Carcinoma ACC-2 Line Cell in vitro[J]. Journal of Fujian Medical University, 2004, 38(3): 275-278 |
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| Authors: | SHI Bin LIN Li song CHEN Nai jun ZHANG Wei jian LIN Geng bin ZHU Xiao feng |
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| Affiliation: | SHI Bin 1,LIN Li song 1,CHEN Nai jun 1,ZHANG Wei jian 2,LIN Geng bin 1,ZHU Xiao feng 1 Department of Oral maxillofacial Surgery,TheAffiliate First Hospital,Fujian Medical University,Fuzhou 350005,China |
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| Abstract: | Objective To investigate the radiosensitizing enhancement effect of paclitaxel on human adenoid cystic carcinoma ACC 2 line cell. Methods ACC 2 was treated by paclitaxel and/or radiation at different time and with different concentration. The survival percent was observed and calculated by cell coloning formation, and then sensitizer enhancement ratios(SER) were evaluated. Results Paclitaxel inhibited ACC 2 proliferation in vitro. Pretreatment of cells with 10, 100, 1000 nmol paclitaxel for 24 h, the SER were 1 29, 1 66, 1 23 respectively. Conclusion Paclitaxel has radiosensitizing enhancement effect on human adenoid cystic carcinoma ACC 2 line cell in vitro. |
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| Keywords: | carcinoma adenoid cystic paclitaxel radiation sensitizing agents tumor cells cultural |
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