霉酚酸酯等新三联在肾移植术后的近期疗效

目的：观察霉酚酸酯（MMF）在预防肾移植术后急性排斥及肺部感染的情况。方法：89例肾移植后应用皮质激素（Perd），环孢素（CsA），MMF（或）硫唑嘌呤（Aza）三联免疫抑制剂治疗，其中分成MMF组52例，Aza组37例，MMF组中适当减少CsA用量。结果：临床观察3个月中，急性排斥（AR）发生率MMF组7．7％（4／52），Aza组16．2％（6／37），肺部感染率MMF组13．5％（7／52），Aza组21．6％（8／37），两者之间存在明显差异（P＜0．05）。结论：MMF组方案对减少AR发生率与并发肺部感染率有一定作用。

Application of Mycophenolate Mofetil ( MMF ) after the Kidney Transplantation

: To the MMFs effect on preventing the acute rejection(AR) and the pulmonary infection after kidney transplantantion. Methods: 89 patients were randomly divided into two groups.One was treated with MMF , while the other was treated with azathioprine (Aza).Both were accompanied with the treatment of cyclosporin A and cortico steroids. The dosage of Cyclospoin A was moderately reduced in the MMF group. Results: Among 52 patients in the MMF group, 4(7. 7% )were found the AR and 7(13.5%) pulmonary infection, while amony 37 patient in Aza group, 6(16.2% )were found AR and 8(21.6%) pulmonary infection. There was significant difference between two groups (P<0.05). Conclusion: MMF can prevent acute rejection and infection pulmonary after the kidney transplantation