造血干细胞移植后出血性膀胱炎的相关因素分析

目的观察造血干细胞移植后出血性膀胱炎的发病情况,探讨其发病危险因素和防治策略。方法回顾分析2006年1月～2009年12月期间88例因恶性血液病行造血干细胞移植患者的临床资料,治疗过程中均进行常规的出血性膀胱炎和移植物抗宿主病预防,分析移植后出血性膀胱炎发生的特点及相关因素。结果共14例患者发生移植后出血性膀胱炎(15.9%),其中5例人类白细胞抗原配型全相合,12例伴有其他部位移植物抗宿主病表现,发生巨细胞病毒感染阳性6人,EB病毒阳性5人。结论在采取充分的预防措施后,出血性膀胱炎仍有发生,而受者CMV感染是造血干细胞移后发生出血性膀胱炎的重要危险因素,而与其他各项因素均无显著相关性。

Risk factors of hemorrhagic cystitis in patients undergoing hematopoietic stem cell transplantation

Objective To explore the characteristics,risk factors,effective prevention and treatment of hemorrhagic cystitis（HC）in patients post hematopoietic stem cell transplantation（HSCT）.Methods From January 2006 to December 2009 the clinical records of eighty-eight patients with hemotologic malignancies after HSCT were reviewed.The relationship between HC and transplantation type or other clinical features was analyzed.Results Fourteen out of eighty-eight（15.9%）patients developed HC after allo-HSCT.Among them,five patients were HLA-identical,twelve presented with graft versus host disease（GVHD）,six patients infected with cytomegalovirus（CMV）,five patients infected with EB virus.Conclusions HC still occured in these patients.The CMV infection of recipients is a important risk factor of hemorrhagic cystitis after HSCT.