| Determination of Aconitine and its Metabolites in Animal Experiment by LC／ESI—MS^n |
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| 引用本文： | ForMaster‘sDegreeDuanMing-Yu Supervisor:Prof,ZHANGHong-gui ZHONGDa-fang ZHANGHan-qi.Determination of Aconitine and its Metabolites in Animal Experiment by LC／ESI—MS^n[J].中国药学,2003,12(1):55-56. |
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| 作者姓名： | ForMaster‘sDegreeDuanMing-Yu Supervisor:Prof ZHANGHong-gui ZHONGDa-fang ZHANGHan-qi |
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| 作者单位： | [1]PharmaceuticalCollege,JilinUniversity,Changchun130021 [2]DepartmentofAnalyticalChemistry,CollegeofChemistry,JilinUniversity,Changchun130023 [3]LaboratoryofDrugMetabolismandPharmacokinetics,ShenyangPharmaceuticalUniversity,Shenyang110016 |
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| 基金项目： | ThisresearchprojectwassupportedbytheNationalNaturalScienceFoundationofChina(3 9870 874and 3 993 0 180 ) |
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| 摘 要： | Aconitumspecies (Ranunculaceae) ,whichdistributewidelyinmiddleandlowerreachesoftheYangziRiver ,northandsouthwestofChina ,containhighlytoxicdiesterditerpeneAconitumalkaloids ,especiallyhighcontentofaconitine .Aconitine ,withanLDforhumanof 3- 5mg ,issometimesusedinsuicidesandhomicidesbecauseofitshightoxicity .Forsearchasmallamountofthetoxicant,itsidentificationisverydifficult.Thus ,forclinicalandforensicmedicine ,amethodforsensitivedeterminationandidentificationofthetoxicantisneeded .Traditio…
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| 关 键 词： | 乌头 乌头碱 代谢物 药物中毒 动物实验 LC／ESI－MS |
Determination of Aconitine and its Metabolites in Animal Experiment by LC/ESI - MSn |
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| Duan Ming-Yu,ZHANG Hong-gui,ZHONG Da-fang,ZHANG Han-qi.Determination of Aconitine and its Metabolites in Animal Experiment by LC/ESI - MSn[J].Journal of Chinese Pharmaceutical Sciences,2003,12(1):55-56. |
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| Authors: | Duan Ming-Yu ZHANG Hong-gui ZHONG Da-fang ZHANG Han-qi |
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| Abstract: | Aconitum species (Ranunculaceae), which distribute widely in middle and lower reaches of the Yangzi River, northand southwest of China, contain highly toxic diesterditerpene Aconitum alkaloids, especially high content of aconitine. |
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| Keywords: | aconitine aconite metabolites LC/ESI-MSn poisoning |
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