巴豆属植物Croton hemiargyerius var.gymnodiscus中生物碱的研究

目的 从巴西巴豆属药用植物的一新变种复制Muel的叶中分离生物碱成分。方法 应用硅胶柱层析法分离和纯化，波谱分析与已知化合物的波谱和理化性质比较得以确定化合物结构。结果 分离得到12个生物碱，其中4个为新生物碱，命名为hemiargineA(1)，B(5)，C(6)和D(7)；8个已知生物碱为isocorydine(2)，corydine(3)，norcorydine(4)，salutaridine(8)，glaucine(9)，tetrahydropalmatrubine(10)，xylopinoine(11)和norlaudanosine(12)。结论 获得4种新化合物，除生物碱(8)，其余生物碱均为首次从该属植物中获得。

The Alkaloids from Leaves of Croton hemiargyerius var.gymnodiscus

Aim Investigation of alkaloids from the leaves of Brazilian medicinal plant Croton hemiargyerius var. gymnodiscus . Methods Silica gel column chromatography was used repeatedly for the isolation and purification, and their structures were identified by extensive spectroscopy and comparison of the chemical and physical data with those of authentic samples reported in literature. Results Twelve alkaloids were isolated and their structures were identified. Conclusion Four new alkaloids named hemiargines A (1), B (5), C (6) and D (7), together with eight known alkaloids namely isocorydine (2), corydine (3), norcorydine (4), salutaridine (8), glaucine (9), tetrahydropalmatrubine (10), xylopinoine (11), and norlaudanosine (12) were isolated.