不同剂量丙种球蛋白治疗川崎病临床疗效观察

目的比较不同剂量丙种球蛋白（IVIG）治疗川崎病的临床效果。方法63例川崎病急性期患儿随机分为A组32例和B组31例。A组给予IVIG0．4g·kg-1·d，连用5d；B组给予IVIG2g·kg-1·d-1用ld。观察2组冠状动脉损害（CAL）发生率和急性期临床症状消失时间。结果B组退热时间、球结膜充血、手足硬肿及淋巴结肿大消退时间均短于A组，冠状动脉损害发生率低于A组，差异均有统计学意义（P〈0．05）。结论IVIG2g·kg-1·d。单次静脉输注为治疗川崎病首选方法。

Clinical effect observation of different dose of gamma globulin in the treatment of kawasaki disease

Objective To study the clinical effect of different dose of gamma globulin in the treatment of kawasaki disease. Methods 63 cases of children with acute phase of kawasaki disease were randomly divided into group A （32 cases） and group B （31 cases）. The group A ： IVIG O. 4 g/kg/D, for five days; the group B ： IVIG 2g/kg/D, for 1 day. The incidence of coronary artery lesions （CAL） and clinical symptoms disappear time in acute stage were compared. Results The antifebrile time, the time of eonjunctival congestion, hand and foot swelling and lymph nodes enlargement and fading away of group B were all shorter than＇those of group A, and the incidence of coronary artery lesions （CAL） was lower than that of group A, and the differences were statistically significant （P 〈 0.05 ） . Conclusion Single intravenous infusion of IVIG 2g/kg. D. is the pre- ferred method in the treatment of kawasaki disease.