Molecular and Epidemiological Characterization of Infant Botulism in Beijing,China |
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| Authors: | DONG Yin Ping WANG Wei JIANG Tao XU Jin HAN Chun Hui YAN Shao Fei LI Ying MA Xiao Chen ZHANG Di ZHAO Yao ZENG Biao LI Feng Qin |
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| Affiliation: | 1. Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment (CFSA), Beijing 100021, China;2. Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China;3. Beijing Centers for Disease Control and Prevention, Beijing 100013, China |
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| Abstract: | Laboratory-based pathogen isolation, identification, and toxicity determination were performed on samples from a suspected case of infant botulism. Mice injected with cultures generated from the enema sample and ingested Powered infant formula(PIF) presented typical signs of botulism. Antitoxins to polyvalent botulinum neurotoxins(BoNTs) and monovalent BoNT type B antitoxin had protective effects. Clostridium botulinum isolated from the enema and residual PIF samples were positive for type B toxin. Pulsed-field gel electrophoresis(PFGE) revealed that the two strains of C. botulinum isolated from the two samples produced indistinguishable pulsotypes. These findings confirmed this case of type B infant botulism associated with the ingestion of PIF contaminated by type B C. botulinum spores. |
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| Keywords: | Clostridium botulinum Infant botulism Powdered infant formula China |
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