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| Quercetin Attenuates Benzo(α)pyrene-induced CYP1A Expression | |
| 基金项目： | This work was supportedby the Russian Foundation for Basic Research;a grant from the Presidium of RAS 'Molecular and Celular Biology' |
| 摘 要： | <正>We studied effects of nutrient quercetin on cytochromes’Р450 1А(CYP1A)activities(measured spectrofluorimetrically using 7-ethoxy-resorufin for CYP1A1 and 7-methoxy-resorufin for CYP1A2 as substrates),on mR NA levels(measured by RT-PCR),and on DNA-binding activities(evaluated by an electrophoretic mobility shift assay)of proteins regulating CYP1A expression in untreated and benzo(α)pyrene(Ba P)-treated rats.Wistar rats |
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