局部灌注沙培林和羟基喜树碱治疗恶性胸腔积液

目的]观察沙培林(0K-432)和羟基喜树碱(HCPT)治疗恶性胸腔积液的近期临床疗效。方法]对62例恶性胸腔积液患者采用胸腔置入贝朗可分裂中心静脉管持续引流，胸腔积液排放完后，给予沙培林5KE胸腔内注入，dl，HCPT30mg胸腔内注入，d2，每周2次，观察临床疗效与不良反应。结果]沙培林与HCPT联合治疗恶性胸腔积液总有效率为88．7％，主要不良反应为发热和骨髓抑制。结论]胸穿置管引流局部灌注沙培林和羟基喜树碱治疗恶性胸积液有较好的近期临床疗效，毒副反应可以耐受。

Intrapleural Instillation with OK-432 and Hydroxycamptothecin for Malignant Pleural Effusion

To observe the efficacy of intrapleural instillation with OK-432and hydroxycamptothecin(HCPT)for patients with malignant pleural effusion.Sixty-two patients with malignant pleural effusion were treated.The PICC tube was inserted into the pleural cavity by pleurocentesis and drained continuously.Intraplerual therapy were given for the patients with OK-4325KE on day1,HCPT30mg on day2,twice a week.The overall response rate(CR+PR)of intrapleural therapy with OK-432and HCPT in malignant pleural effusion was88.7%.The major side effect was bone marrow suppression and fever.Conclusions]For patients with malignant pleural effusion,intrapleural therapy with OK-432and HCPT has showed a better clinical short-term effect.The toxicity is tolerant.