| 原癌基因Wip1的研究进展 |
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| 引用本文： | 张伟,顾勇,罗红鹤,赵吉星.原癌基因Wip1的研究进展[J].中国病理生理杂志,2008,24(7):1445-1448. |
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| 作者姓名： | 张伟 顾勇 罗红鹤 赵吉星 |
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| 作者单位： | 中山大学附属第一医院胸外科， 广东 广州 510080 |
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| 摘 要： | 细胞DNA总是受到来自环境和内源性致突变因素攻击.为保持基因组的完整性和抑制肿瘤发生,细胞在长期检查点机制.
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| 关 键 词： | 基因 Wip1 p38MAP激酶 蛋白质p53 |
| 收稿时间： | 2007-12-13 |
| 修稿时间： | 2008-6-12 |
Progress in a new proto-oncogene of Wip1 |
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| ZHANG Wei,GU Yong,LUO Hong-he,ZHAO Ji-xing.Progress in a new proto-oncogene of Wip1[J].Chinese Journal of Pathophysiology,2008,24(7):1445-1448. |
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| Authors: | ZHANG Wei GU Yong LUO Hong-he ZHAO Ji-xing |
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| Institution: | Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat - sen University, Guangzhou 510080, China. E-mail: guyong64@163.com |
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| Abstract: | Wip1 is a nuclear protein and a member of serine/threonine specific protein phosphatase type 2C(PP2C)family.It was initially identified as a gene whose expression was induced in response to γ or UV radiation in a p53-dependent manner and a negative feedback regulation of p38MAPK-p53 signaling. Then,Wip1 gene was confirmed a proto-oncogene and amplified or overexpressed in several human tumor types. This review will introduce the structures and functions of Wip1 and details on the signaling process of cancer progression. |
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