| 抗精神病药物治疗的“三五”原则 |
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| 引用本文： | 张文和.抗精神病药物治疗的“三五”原则[J].中国新药与临床杂志,2006,25(8):619-624. |
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| 作者姓名： | 张文和 |
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| 作者单位： | 慈济医学中心精神医学部,台湾,花莲,970 |
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| 基金项目： | 致谢 本文系作者以2006年3月9日在上海的演讲为蓝本,加以整理而成.承蒙顾牛范教授现场邀稿,谨此致谢. |
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| 摘 要： | “三五”原则是指：(1)选药的“五要”原则,即有效、安全、便宜、方便及易换；(2)确保安全的“五不要”守则,即避免锥体外症候群、高催乳素血症、并用抗精神病药物、与抗胆碱能药物联用及体重增加；(3)必须停药(或换药)的5种最“要不得”意外,即抗精神病药物恶性症候群、粒性白血球缺乏症、急性心肌炎、心室性传导障碍及新发Ⅱ型糖尿病。
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| 关 键 词： | 精神分裂症 抗精神病药物 药物疗法 选药原则 药物不良反应 |
| 文章编号： | 1007-7669（2006）08-0619-06 |
| 收稿时间： | 2006-04-13 |
| 修稿时间： | 2006-04-132006-06-28 |
"Triple-five" principles of antipsychotic treatment |
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| ZHANG Wen-he."Triple-five" principles of antipsychotic treatment[J].Chinese Journal of New Drugs and Clinical Remedies,2006,25(8):619-624. |
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| Authors: | ZHANG Wen-he |
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| Institution: | Department of Psychiatry, Tzuchi General Hospital, Hualien TAIWAN 970, China |
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| Abstract: | This article reviews guidelines for the choice of antipsychotics in the treatment of schizophre- nia.At least five major factors are essential for the consideration in clinical practice.These include efficacy,ad- verse reactions,costs,convenience of use and easy to switch.Moreover,five important safety considerations which should be emphasized in the selection and use of first-line atypical antipsychotics are listed as follows: (1)to avoid extrapyramidal symptoms;(2)to avoid hyperprolactinemia;(3)to avoid antipsychotic polyphar- macy;(4)to avoid anticholinergic medication;and(5)to avoid weight gain.In addition,five serious ad- verse reactions may require switching to an alternative agent.These include:(1)neuroleptic malignant syn- drome;(2)agranulocytosis;(3)myocarditis;(4)cardiac rhythm abnormalities;and(5)impaired glu- cose tolerance. |
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| Keywords: | schizophrenia antipsychotic agents drug therapy drug choice adverse drug reactions |
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