盐酸利多卡因在高原汉族健康志愿者体内的药物动力学研究

目的研究盐酸利多卡因在高原汉族健康志愿者体内的药物动力学特征。方法采用RP-HPLC法测定人血浆中药物浓度,色谱柱为Lichrospher C18（4.6×250 mm,5μm）,流动相为乙腈-甲醇-0.5%冰乙酸溶液（15：20：50,v/v）。DAS 2.0软件计算药物动力学参数。结果盐酸利多卡因在高原汉族志愿者的t1/2为（2.44±0.69）h,AUC（0-t）为（7.43±1.86）μg.h/mL,MRT（0-t）为（2.37±0.31）h,Tmax为（0.56±0.17）h,Cmax为（2.78±0.54）μg/mL,CL为（1.24±0.34）L/h,V为（4.31±1.48）L。结论盐酸利多卡因在高原汉族健康志愿者体内吸收迅速,半衰期较平原志愿者显著延长。

THE PHARMACOKINETICS OF LIDOCAINE HYDROCHLORIDE IN HAN HEALTHY VOLUNTEERS LIVING AT HIGH ALTITUDE

Objective To study the pharmacokinetics of lidocaine hydrochloride in Han healthy volunteers living at high altitude.Methods The concentration of lidocaine was determined by RP-HPLC method,the analysis involved a 250 mm × 4.6mm column packed with C18（5 μm）,the mobile phase consisted of acetonitrile-methyl alcohol-0.5%glacial acetic acid（15∶20∶50）.Results The pharmacokinetics parameters t1/2 of lidocaine in Han volunteers was 2.44±0.69 h,AUC（0-t） was 7 7.43±1.86 μg.h/ml,MRT（0-t） was 2.37±0.31 h,Tmax was 0.56±0.17 h,Cmax was 2.78±0.54 μg/ml,CL was 1.24±0.34 L/h,V was 4.31±1.48 L,respectively.Conclusion The results demonstrated that lidocaine hydrochloride has rapid absorption in Han healthy volunteers living at high altitude,and its half-life time is significantly increased compared with volunteers living at plain.